Lifeline® ProPlus Day & Night Duo

Diminish wrinkles & fine lines, lift & firm skin, reduce discolorations, & shrink pores.


(10 customer reviews)

2 Applications a Day to Look Young Again

Life Line Stem Cell Skin Care

“I was looking for a serum to help give my skin a more youthful appearance. It’s not greasy and gives my skin a silky feel.”

Evelyn Appleton

  • Highly concentrated with healing & de-aging parthenogenetic stem cells.
  • Reduces wrinkles, sagging skin, discoloration, & more.
  • Non-greasy formula & non-comedogenic.
  • Each tube lasts for 5-6 weeks.

Lifeline® ProPlus+ was developed by a celebrated M.D., Ph.D and is the most effective anti-aging skincare system available. This quick and easy two-part system contains more effective ingredients than any other product in the world.

FREE shipping on all orders over $150. Delivery in 2-3 business days.

Lifeline® ProPlus is a professional line of products containing more stem cells/growth factors than regular Lifeline products. The ProPlus collection is only available through physician partners and skin care professionals.

before-afters Lifeline® ProPlus+ Duoe Before & After 1 Month

“This is excellent! I am in my mid-60’s and my skin is remarkably smooth, with very few wrinkles. I am a customer for life!”

Barbara Faye

Paraben, Gluten, & Silicone Free. Not tested on animals.

The Most Advanced Way to Reverse Aging Skin

  • Anti-inflammatory parthenogenetic stem cell peptides, growth factors, enzymes, and cytokines are the most advanced & effective way to reverse skin aging.
  • Anti-aging, healing and anti-inflammatory benefits.
  • Improves the health and overall appearance of the skin.
  • Assists with a more rapid recovery following medical esthetic procedures. The Lifeline Propus duo is the #1 stem cell/growth factor product!
  • When compared head to head with it’s competitors including AnteAgeMD, it wins, hands down! Voted best by Truth in Aging.

Daytime: Lifeline® ProPlus+ Daily Defense Complex

  • Immediately begins restoring your skin’s ability to heal and regenerate.
  • Absorbs quickly – utilizes nanotechnology to deliver a powerhouse of physiologically balanced stem cytokines™, potent peptides, ultrasomes, and protective antioxidants.
  • Pair with Lifeline® ProPlus+ Recovery Night Moisture Serum for best results. The Lifeline Proplus duo works synergistically to give amazing results.

Nighttime: Lifeline® ProPlus+ Recovery Night Moisture Serum

  • Rich in powerful moisturizers, vitamins, & parthenogenetic stem cell extracts.
  • Wake up to firmer, more radiant, & younger looking skin.
  • Pair with Lifeline® ProPlus+ Daily Defense Complex for best results.

Together, the Lifeline ProPlus Duo will:

  • Reduce lines & wrinkles.
  • Improve skin texture, firmness, & sagging.
  • Reduce pigmentation, redness, & dryness.
  • Shrink visible pore size.

Pair with Lifeline® ProPlus+ Eye Firming Complex and Lifeline® ProPlus+ Neck Firming Complex to get the full Lifeline® ProPlus+ anti-aging skin care experience.

How long does it take?

  • Within 24 hours – reversal of dry skin begins.
  • Within 1-2 weekreversal of skin dullness & texture improvement.
  • Within 2-3 weeks reversal of redness – including rosacea.
  • Within 4-5 weeks – reversal of fine lines & noticeably firmer skin. Clinical studies recorded a 30% reduction of lines and wrinkles.
  • Within 5 weeks – reversal of melasma – skin pigmentation – common in women post pregnancy.
  • Within 8 weeks – visibly diminished pore size.
  • Within 12 weeks – very noticeably firmer skin. Clinical studies studies measured a 77% improvement in wrinkle length & depth.

In comparison with other stem cell skin care products, Lifeline® ProPlus+ products are a completely new way to treat wrinkles, age spots, and lack of skin firmness. No more wasted money with products you layer on top of the skin, hoping it will plump up those wrinkles or fade those age spots.

Lifeline® ProPlus+ uses nanotechnology to create microscopic molecules which penetrate the skin, delivering stem cell extracts to the layers of skin where collagen and elastin are made. It’s the only stem cell product line able to deliver the good stuff right to the dermis.

In the dermis, where you find collagen and elastin, the stem cell extracts communicate with your skin cells. The result is a proliferation of new skin cells. You will see, based on scientific studies, a 77% reduction in wrinkle length and depth in 3 months. You will see lifting, firmness, toning, and luminescence you haven’t seen for years.

In fact, you will see skin that behaves like it did years prior to beginning usage of these Lifeline® ProPlus+ products. 90% of study participants noticed firmer, tighter skin within 3 months. 59% noticed a visible reduction of lines and wrinkles within one month and within 3 months cutometer readings showed a 77% reduction in length and depth of wrinkles. At this time, 87% said that they felt that their appearance was remarkably improved.

Morning and bedtime:

Apply 2 pumps of the daytime or nighttime serum to a clean dry face*. Neck and décolletage treatment requires an extra pump.

Less than two minutes, twice a day, is all it takes to start on an immediate path to looking younger. These highly advanced and smooth-feeling serums absorbs immediately into your skin, utilizing nanotechnology to deliver a powerhouse of Stem Cell Cytokines, Protective Antioxidants, and Potent Peptides.

*If you are using Retin-A, you apply that in a thin layer first, then the serum.
*If you are using hydroquinone, you apply that first, then the serum.

Lifeline® ProPlus+ Skin Care researchers and formulators combined the latest discoveries in the fields of stem cell biology, nanotechnology, and skin products formulation technology to create the highest quality, scientifically tested and most effective anti-aging skincare products. Lifeline® ProPlus+ Stem Cell Extract Serums are the only products in the world that contain human, non-embryonic stem cell extracts.

Only International Stem Cell Corporation (Lifeline®’s parent company) has a patented way to take human eggs and stimulate them to begin dividing, without being fertilized.

They’re called parthenogenetic stem cells (“partheno” comes from the Greek word for virgin). To produce these stem cells, an embryo is never created, so it’s never destroyed—that’s why it’s an ethical approach to creating stem cells.

While the stem cells are still pluripotent, scientists extract growth factors, cytokines, enzymes, and peptides for use in Lifeline® ProPlus+ stem cell serums. Because they’re several generations away from the source, adult stem cells (such as from skin, blood, fat or bone marrow) are far less potent than stem cells closer to the original egg-the parthenogenetic stem cells used in Lifeline® ProPlus+ products.

Non-embryonic stem cells are by far the most potent human stem cells that we can ethically use.

For more science, click here.

Once I find what I am looking for, how do I buy it?

When you find an item or items you wish to purchase:
1. Click on the link that reads “Add To Cart”, next to the item description and price. This will add the item to your shopping cart and this then brings you to the cart page which lists all of the products that you have previously selected.
2. On the cart page, you may change the quantities, and then you’ll need to press the “update quantity” link. Your cart will remain available if you leave the page to add new items and return to cart.
3. The cart page will reload and display the total cost of your order. If it does not, just refresh your browser.
4. Click “Proceed to Checkout”, once you are satisfied with your shopping cart contents.
5. After submitting your order, you will receive an email Order Confirmation. If you have difficulties of any sort just call us at (772) 999-5322.

I want to return my Lifeline® ProPlus+ product, can I return it?

If you have questions or concerns, please email us or call us at (772) 999-5322. We are very committed to your satisfaction. You may return any unopened item within 30 days of purchase for a full refund. If your opened product is defective upon shipping, do not use it and we will replace it with the same item.

We will not charge you any shipping to ship a replacement item. Shipping fees, both to and from you, are nonrefundable, and you will be charged a 10% restocking fee, unless the return was made as a result of our error.

Not happy with results? View our money back guarantee.

Are your products safe for pregnant women to use?

Our products are gentle and effective for all skin types. However, we recommend that any woman who is pregnant or breast-feeding check with her physician before changing her skin care routine.

Our products are not tested on animals.

Can men use these products?

Absolutely and positively yes they can. A man’s facial skin is just as sensitive as a woman’s. Products that claim to be strong enough for a man generally have drying and abrasive ingredients like alcohol, silicone based lubricants, petroleum based skin softeners and harsh preservatives that will dry and irritate the skin. Lifeline® ProPlus+ products are as simple and natural as possible to help fight inflammation and balance the skin.

Additional information


Lifeline® ProPlus+

Skin Concerns

Anti-Aging, Discoloration, Dryness, Dullness, Fine Lines & Wrinkles, Firmness / Elasticity, Pores, Redness, Skin Inflammation, Uneven Skin Tone

Focus Area

Face & Neck


Antioxidant, Non-Comedogenic

Key Ingredients

Stem Cell Peptides

Skin Type

All Skin Types

10 reviews for Lifeline® ProPlus Day & Night Duo

  1. Lisa M. Scott

    This is truly the most amazing skin care product I have ever tried. All this hype about Stem Cells seems to be justified after all. I began seeing results during the first month of use and my skin appearance and texture and firmness are still improving steadily even after 5 months. I tried a LOT of skin lotions, creams, serums, you name it, reading the sales pitch, they always promised wonders and I always felt somewhat disappointed after using the products. Not this time; this combo really does WONDERS… This is by far the best skin care regimen out there in my opinion. The quest is over for me, I’m sticking to this Lifeline Proplus combination…

  2. Amy Nonos

    These are the most amazing anti aging skin products I have ever used in my life! I saw results in a week,wow!

  3. Roberta

    Beyond amazing! I live in the northeast and suffer from intense dry skin in the winter. The combination of these products not only improve skin texture, tone and hyper pigmentation but serves as an amazing moisturizer. And yes indeed, FIRMER skin! No break outs just beautiful skin!

  4. Anthony Longelli

    Amazing products! I look 10 years younger after a month!

  5. RIcky Hale

    WOW! Price had me concerned at first. I usually don’t spend so much on a product, but totally worth it. Just incredible difference from what was to what my skin looks like now. Absolutely the best anti aging serum I’ve ever used. And the reviews speak for themselves, go glad that I decided to listen for once and try this. Maybe just the best anti aging product on the market.

  6. Carmilla Vesquez

    A couple of weeks using these products and my skin looks beautiful. Fine lines and wrinkles are diminished, tone is more even. Hydrates skin without being too greasy.

  7. Karen Holcombe

    Amazing product! Exactly 9 days in and I can’t believe the results. My skin hasn’t been this soft and glowing for decades! So so happy, thank you for the recommendation!

  8. Dottie Crane

    First things first, I am a licensed Esthetician and Makeup Artist, so I have an in depth knowledge of skincare, and how different product ingredients work on the skin. This is an amazing product! I noticed a difference in the texture of my skin immediately after applying the serum to my face. It leaves your skin feeling smooth and hydrated without leaving any kind of residue or sticky feeling. The Lifeline Proplus Duo is great for ANY skin type, and will get you looking glowing and youthful in no time!

  9. DK

    I just started using the Lifeline duo, after 5 days, I’m thrilled to continue using these products

  10. Dr. Kim Crawford

    My pleasure!

  11. Karen Nightingal

    This is the best skin care serum package. Mild soft and natural smell and makes your skin feel like satin. I have allergies to a lot of things and this has never bothered me. Totally non-greasy feel both day and night. And after just the first week my skin was brighter and more even. Each week I see lines and spots fading. I got the night serum first and saw effects but you are right-you see more results with these two. I’m going to add the eye serum to my next order. 5 star product for sure.

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